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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Dextroamphetamine and Dexmedetomidine

Research Papers that Mention the Interaction

Dexmedetomidine inhibited D-amphetamine-induced hyperlocomotion and the L-5-hydroxytryptophan-induced serotonin syndrome, but the inhibition was attenuated in mice lacking alpha2C-adrenoceptors.
Neuroscience  •  1998  |  View Paper
After dexmedetomidine, d-amphetamine dramatically decreased mean time to emergence compared to saline (saline:112.8 ± 37.2 min; d-amphetamine:1.8 ± 0.6 min, p < 0.0001).
In this study, we tested the hypothesis that d-amphetamine accelerates recovery of consciousness after dexmedetomidine and ketamine.
These findings suggest that d-amphetamine may be clinically useful as a reversal agent for dexmedetomidine.
Frontiers in Pharmacology  •  2021  |  View Paper