Possible Interaction: Dextroamphetamine and Aripiprazole

“Administration of aripiprazole significantly attenuated the discriminative-stimulus and cardiovascular effects of D-amphetamine , as well as some of the subject-rated drug effects.”

“Another contributing factor for case 2 could be the potential for aripiprazole to attenuate the stimulant effect of dextroamphetamine.”

“Acutely administered aripiprazole attenuates the discriminative stimulus and other behavioral effects of d-amphetamine in humans; however, whether aripiprazole attenuates the effects of more commonly abused stimulants is unknown.”

“In a previous study from our laboratory, 20 mg aripiprazole , an atypical antipsychotic that has partial agonist activity at D(2) receptors, attenuated many of the behavioral effects of d-amphetamine.”

“The present experiment was conducted to determine whether a lower dose of aripiprazole (10 mg) could acutely attenuate the discriminative-stimulus, subject-rated, and physiological effects of d-amphetamine (2.5-15 mg) without impairing performance as measured with a computerized version of the DSST.”

“The results of the present experiment indicate that 10 mg aripiprazole attenuated some abuse-related behavioral effects of d-amphetamine and was generally devoid of effects, including significant performance impairment, when administered alone.”

“ Aripiprazole (10 mg) failed to alter the discriminative-stimulus effects but attenuated some of the subject-rated effects of d-amphetamine.”

“Co-administration of aripiprazole and d-amphetamine for 7 d resulted in aripiprazole counteracting the d-amphetamine-induced sensitization in facilitation of brain reward function and hyperlocomotion.”

“… aripiprazole may be associated with potentiation of dopaminergic activity.6 Pramipexole … the use of the combination of clomipramine 300 mg, dextroamphetamine 30 mg, pramipexole 3 mg, lithium 900 mg, and quetiapine 200 mg daily in … use of combination therapy (clomipramine, dextroamphetamine, pramipexole, and aripiprazole) for ECT-resistant unipolar depression.”