Possible Interaction: Dextroamphetamine and Antipsychotic Agents

“Classical antipsychotic drugs from different chemical classes were all able to block the AMPH cue.”

“The AMPH cue was also antagonized by antipsychotic drugs that are considered atypical due to their relative lack of activity in conventional animal models or inability to produce extrapyramidal symptoms in the clinic.”

“On the evidence that the administration of some antipsychotic drugs and d-amphetamine , separately and in combination, induced changes in the concentration of striatal p- and m-tyramine, it is proposed that the tyramines may possess a role in neural function.”

“Results: We observed that all three antipsychotics dose-dependently reversed the disruptive effect of d-amphetamine after acute or sub-chronic treatment, but that this reversal effect disappeared after chronic treatment.”

“Hypodipsia produced by injection of d-amphetamine (2.0 mg/kg) or apomorphine (0.8 mg/kg) in rats, was partially antagonized by two DA-specific neuroleptic drugs , Pimozide and Spiramide, respectively.”

“ Antipsychotic drugs can inhibit the effects of phencyclidine (PCP) and d-amphetamine (AMPH) in many rodent tests, but the effects are usually seen at doses that also affect vehicle-treated control rats, suggesting that the inhibition may be nonspecific.”

“A simple and rapid screening method, where the ability of neuroleptic drugs to antagonise the abnormal pattern of exploration induced by a low dose of d-amphetamine in a 10 min test, was evaluated.”

“After rats were trained to differentiate between the effects of intraperitqoneal administration of 0.6 mg/kg d-amphetamine and saline, pretreatment with various neuroleptic drugs was observed to significantly inhibit d-amphetamine discrimination.”

“The results indicate that neuroleptics differ markedly in their specificity of antagonism of DMT and d-amphetamine which may act through different neurotransmitter mechanisms (tryptaminergic vs. adrenergic).”

“Clinically potent neuroleptics such as haloperidol and chlorpromazine can effectively reverse the polysome dissociation as well as the behavioral changes induced by a near toxic dose of d-amphetamine (15 mg/kg).”

“Thus, after discontinuation of antipsychotic treatment , D1-and D2-mediated transmission differentially modulate the expression of a supersensitive response to d-amphetamine.”