Possible Interaction: Dextran and Calcium Supplement

“To circumvent this issue, calcium probes conjugated to dextran can be used to enhance the hydrophilicity and reduce the nonspecific interaction and compartmentalization.”

“We have recently noted that total serum protein concentrations from …-year-old woman and a 64-year-old man receiving dextran 40 (…, CA , USA) were as unexpectedly high as 200% over the basal value within the …–10 g/L), as measured with the Bayer reagent (Bayer Diagnostics, Dublin, Ireland).”

“Significant correlations were found between increased molecular size of the dextran sulfates and inhibition of both PDGF binding (r=0.77) and Ca2+ release (r=0.72).”

“It has been shown that threshold concentrations of calcium necessary to induce liposome aggregation in the presence of approximately 1 mM concentration of dextran is about one order lower than in the absence of dextran.”

“When dextran or dextran sulfate was combined with PTH, the amount of calcium released was significantly greater than dextran or dextran sulfate alone but not from PTH when tested alone.”

“The injection of dextran sulfate resulted in a significant increase of spleen weight, with a transitory increase of calcium concentration in the three tissues and a significant decrease of iron level in the spleen.”

“Low doses of calcium inhibited the local anaphylactoid response of rat paw and skin to dextran.”

“Attachment of dextran , irrespective of its molecular weight (18.5-440 kDa), increased the stability of emulsions against calcium induced flocculation, demonstrating that a low molecular weight dextran is sufficient for imparting high steric stability.”

“The cooperative effects of dextran and calcium ions promoted aggregation of particles at a concentration as low as 12%.”