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Last Updated: 2 years ago

Possible Interaction: Dexrazoxane and Iron, Dietary

supplement:

Iron, Dietary

Research Papers that Mention the Interaction

Dexrazoxane appears to complex with metal co-factors including iron , to reduce the incidence of anthracycline-induced cardiotoxicity, allowing the delivery of higher cumulative doses of anthracyclines without the expected consequence of cardiomyopathy.
Drugs  •  1999  |  View Paper
Clinical studies have also found that chelation of iron with deferoxamine and dexrazoxane acutely improves endothelial function in subjects with coronary artery disease, and in normal subjects with homocysteine-induced endothelial dysfunction [1, 10].
European Journal of Nutrition  •  2013  |  View Paper
Dexrazoxane presumably exerts its cardioprotective effects by either binding free or loosely bound iron , or iron complexed to doxorubicin, thus preventing or reducing site-specific oxygen radical production that damages cellular components.
Current medicinal chemistry  •  1998  |  View Paper
Dexrazoxane presumably exerts its cardioprotective effects by either binding free or loosely bound iron , or iron complexed to doxorubicin, thus preventing or reducing site-specific oxygen radical production that damages cellular components.
Seminars in oncology  •  1998  |  View Paper