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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dexrazoxane
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“ Dexrazoxane appears to complex with metal co-factors including iron , to reduce the incidence of anthracycline-induced cardiotoxicity, allowing the delivery of higher cumulative doses of anthracyclines without the expected consequence of cardiomyopathy.”
Chemoprotectants: a review of their clinical pharmacology and therapeutic efficacy.“Clinical studies have also found that chelation of iron with deferoxamine and dexrazoxane acutely improves endothelial function in subjects with coronary artery disease, and in normal subjects with homocysteine-induced endothelial dysfunction [1, 10].”
“ Dexrazoxane presumably exerts its cardioprotective effects by either binding free or loosely bound iron , or iron complexed to doxorubicin, thus preventing or reducing site-specific oxygen radical production that damages cellular components.”
Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines.“ Dexrazoxane presumably exerts its cardioprotective effects by either binding free or loosely bound iron , or iron complexed to doxorubicin, thus preventing or reducing site-specific oxygen radical production that damages cellular components.”
Chemistry of dexrazoxane and analogues.
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