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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Dexrazoxane
supplement:
Ferric Ion
Research Papers that Mention the Interaction
“ Dexrazoxane exerts its protective effects by rapid and complete binding of ferric and ferrous ions, even by displacing the metal ions from complexes with anthracyclines.”
[Dexrazoxane (ICRF-187)--a cardioprotectant and modulator of action of some anticancer drugs].“While dexrazoxane itself did not undergo any iron-promoted … hydrolysis, both ferrous (t1/2 0.4 min) and ferric (t1/2 170 min) ions promoted, by factors of up to … 8, respectively, the hydrolysis of the one-ring open intermediates of dexrazoxane to yield the strongly …-ion-chelating form.”
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