Possible Interaction: Dexamethasone and Vitamin D

“… vitamin D3 resulted in an enhanced broad‐spectrum proinflammatory cytokine response of cord blood mononuclear cells to innate and mitogenic stimuli (P = .0009), with an … in IL‐17A (P = .03) production after polyclonal T‐cell stimulation, and an enhanced IL‐10 response of cord blood mononuclear cells to dexamethasone …).”

“Tolerogenic dendritic cells (tolDCs) generated from monocytes by a combined treatment with vitamin D and dexamethasone (marked by CD52hi and CD86lo expression) induce antigen-specific Tregs.”

“Conclusion The curative effect of alphacalcidol combined with dexamethasone on pulmonary fibrosis is better than either dexamethasone or alphacalcidol alone, and the mechanism may be related to the inhibition of TGF-β1 and inflammatory factors.”

“CONTEXT Altered vitamin D and calcium homeostasis may play a role in the development of type 2 diabetes mellitus ( type 2 DM).”

“SNP rs1042522 genotypes in the dominant form (CG + GG vs. CC ) (OR= 3.880; P < 0.001) and alleles G vs. C alleles (OR= 0.384; P < 0.001) increased the risk of type 2 DM significantly.”

“The analysis demonstrated an inverse association between vitamin D and the development of several autoimmune diseases, such as SLE, thyrotoxicosis, type 1 DM , MS, iridocyclitis, Crohn's disease, ulcerative colitis, psoriasis vulgaris, seropositive RA, polymyalgia rheumatica.”

“ResultsPatients with DM had lower levels of total BGP (139.00 vs. 202.50 mcg/L, p < 0.001), 25(OH)D (23.4 vs. 30.2 ng/ml, p < 0.001), and ucBGP (9.24 vs. 11.32 mcg/L, p = 0.022).”

“When studying the mechanisms of the effects of Vit D on tenocytes, reactive oxygen species produced by Dex decreased with Vit D , and the phosphorylation of extracellular signal–regulated kinase and p38 was stimulated by Vit D cotreatment.”

“The effect modification by persistent hyperglycemia persisted in the multivariate analysis (pinteraction = 0.01).ConclusionsLow 25(OH)D may increase TB risk in patients with underlying DM.”

“ Vitamin D could be a mediator in the association between TB and DM.”

“Furthermore, pre-treatment with Dex inhibits vitamin D3 induced cathelicidin expression in THP-1 monocytes, primary monocytes and in the human bronchial epithelial cell line BCi NS 1.1.”