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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dexamethasone
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“ Dexamethasone inhibited this effect in a dose-dependent manner both in the presence and absence of vitamin B6.”
“Induction of a glucocorticoid response element (GRE)-driven promoter construct by dexamethasone in lymphoid cells was only marginally reduced by vitamin B6.”
Vitamin B6 modulates glucocorticoid-dependent gene transcription in a promoter- and cell type-specific manner.“However, recentrifugation of either the 8.0 S peak from untreated cytosol or the 5.7 S peak from … cytosol resulted in a single peak which sedimented at 8.0 S. These results suggest that 5 mM pyridoxal phosphate causes the … of the dexamethasone receptor complex to a … form.”
“The treatment of cells with dexamethasone transiently upregulated the expression of both genes with peak mRNA levels of approximately 10‐fold over control levels occurring at day 3 for the PLP gene and at day 5 for the MAG gene.”
Glucocorticoid‐induced upregulation of proteolipid protein and myelin‐associated glycoprotein genes in C6 cells“ Pyridoxal-5'-P also caused a 52% and 92% inhibition of nuclear binding of [3H]dexamethasone in the glands at 2 mM and 5 mM concentration in the presence of the same hormones in the medium.”
“99, 1203-1208), pyridoxal phosphate appears to modulate the enzyme-inducing activity of dexamethasone in L-cells but not the polysome and ribosome related changes.”
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