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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dexamethasone
supplement:
Vitamin A
Research Papers that Mention the Interaction
“Exogenous steroid therapy dexamethasone ), which is often used to improve pulmonary compliance in ventilated premature infants, may compromise vitamin A status and induce restricted somatic and bone mineral growth.”
Special nutritional needs of infants for prevention of and recovery from bronchopulmonary dysplasia.“A significant, yet short-term, increase in plasma concentrations of both vitamin A and RBP was observed in most infants treated with dexamethasone.”
“BPD infants who received postnatal dexamethasone during their hospital course had a higher day-28 baseline retinol concentration (1.19 +/- 0.15 mumol/L) than did the group with no BPD (0.82 +/- 0.06 mumol/L) (P = 0.03).”
“ Vitamin A up-regulated DSP-PP expression as did dexamethasone.”
Effects of dexamethasone, vitamin A and vitamin D3 on DSP-PP mRNA expression in rat tooth organ culture.“We conclude that a prompt, sustained, and selective decrease in the fetal lung stores of vitamin A appears to occur following maternal antenatal dexamethasone treatment.”
“ Dexamethasone increased serum retinol concentrations in the SD group (2.27 ± 0.20 μmol/L) when compared with control (SP, 1.64 ± 0.46 n,mol/L, p < 0.001) as well as with pretreatment baseline values (1.21 ± 0.23 μmol/L, p < 0.001).”
“ Dexamethasone increases serum retinol and retinol-binding protein concentrations in vitamin A sufficient rats, apparently at the expense of both lung and liver total vitamin A, retinol, and retinyl ester concentrations.”
“The Addition of 2 microM retinol resulted in a 3-fold increase in specific dexamethasone binding in the epidermal cytosol within 12 h with no change in the binding affinity.”
“The induced enzyme activity in cell lysates prepared from cells treated with retinol and dexamethasone had a Vmax that was 50-fold that of the controls.”
“When studied over a wide range of concentrations, retinol and dexamethasone incubated together produced approximately additive increases in the accumulation of RBP.”
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