Possible Interaction: Dexamethasone and Tyrosine

“These effects were parallel to the ability of m-Tyr to improve the pro-inflammatory effects induced by LPS and inhibit the anti-inflammatory action of dexamethasone.”

“Analysis of signaling pathway revealed that tyrosine phosphorylation of Src kinase was dramatically increased in response to FGF-2 and DEX , suggesting the involvement of Src-dependent pathways in the stimulatory mechanism of proliferation of ATSCs by FGF-2 and DEX.”

“ Dexamethasone , 10(-7) mol/L, increased levels of tyrosine phosphorylation of both proteins within 15 to 30 minutes without a change in protein levels.”

“ Dexamethasone increased (approximately twofold) the tyrosine phosphorylation of 120-, 110-, and 77-kDa proteins in cell extracts, and herbimycin A selectively blocked the phosphorylation of the 110-kDa phosphoprotein.”

“Furthermore, the level of phosphorylation on tyrosine (204) essential for MAP kinase activation was decreased after Dexa treatment.”

“Accordingly, the plasma ratios between L‐TRP and tyrosine and the sum of the competing amino acids were significantly reduced by dexamethasone administration.”

“ Dexamethasone significantly suppressed the availability of L-TRP (P less than 10(-5] and of tyrosine (P = 0.005).”

“Treatment with dexamethasone also enhanced tyrosine phosphorylation of Dok-1, augmented recruitment of Ras GTPase-activating protein (RasGAP) by Dok-1, and inhibited activation of the mitogen-activated protein (MAP) kinase pathway in antigen-stimulated cells.”

“We demonstrate in this work that dexamethasone , a synthetic GC, inhibits the early signaling events initiated upon TCR ligation, such as tyrosine phosphorylation of several TCR-associated substrates including the ζ chain, the ZAP70 kinase, and the transmembrane adapter molecule linker for activation of T cells.”

“Furthermore, dexamethasone down‐regulated insulin receptor substrate‐1 protein content by 42% and insulin‐induced tyrosine phosphorylation of insulin receptor substrate‐1 by 28%.”