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Last Updated: 6 months ago

Possible Interaction: Dexamethasone and Tyrosine

supplement:

Tyrosine

Research Papers that Mention the Interaction

Analysis of signaling pathway revealed that tyrosine phosphorylation of Src kinase was dramatically increased in response to FGF-2 and DEX , suggesting the involvement of Src-dependent pathways in the stimulatory mechanism of proliferation of ATSCs by FGF-2 and DEX.
Tissue engineering. Part A  •  2009  |  View Paper
Dexamethasone , 10(-7) mol/L, increased levels of tyrosine phosphorylation of both proteins within 15 to 30 minutes without a change in protein levels.
The Journal of laboratory and clinical medicine  •  1999  |  View Paper
Dexamethasone increased (approximately twofold) the tyrosine phosphorylation of 120-, 110-, and 77-kDa proteins in cell extracts, and herbimycin A selectively blocked the phosphorylation of the 110-kDa phosphoprotein.
Canadian journal of physiology and pharmacology  •  1999  |  View Paper
Furthermore, the level of phosphorylation on tyrosine (204) essential for MAP kinase activation was decreased after Dexa treatment.
Leukemia  •  1997  |  View Paper
Accordingly, the plasma ratios between L‐TRP and tyrosine and the sum of the competing amino acids were significantly reduced by dexamethasone administration.
Acta psychiatrica Scandinavica  •  1990  |  View Paper
Dexamethasone significantly suppressed the availability of L-TRP (P less than 10(-5] and of tyrosine (P = 0.005).
Journal of affective disorders  •  1990  |  View Paper
Treatment with dexamethasone also enhanced tyrosine phosphorylation of Dok-1, augmented recruitment of Ras GTPase-activating protein (RasGAP) by Dok-1, and inhibited activation of the mitogen-activated protein (MAP) kinase pathway in antigen-stimulated cells.
Molecular Pharmacology  •  2005  |  View Paper
We demonstrate in this work that dexamethasone , a synthetic GC, inhibits the early signaling events initiated upon TCR ligation, such as tyrosine phosphorylation of several TCR-associated substrates including the ζ chain, the ZAP70 kinase, and the transmembrane adapter molecule linker for activation of T cells.
The Journal of experimental medicine  •  2001  |  View Paper
Furthermore, dexamethasone down‐regulated insulin receptor substrate‐1 protein content by 42% and insulin‐induced tyrosine phosphorylation of insulin receptor substrate‐1 by 28%.
FEBS letters  •  1998  |  View Paper
In contrast, dexamethasone decreased both tyrosine phosphorylation and expression of insulin receptor substrate 1 (IRS-1) and IRS-1-associated phosphatidylinositol 3-kinase activity.
The Journal of clinical investigation  •  1995  |  View Paper
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