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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dexamethasone
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“ S1P significantly enhanced COX-2 expression and PGE2 secretion, and this was repressed by the selective COX-2 inhibitor celecoxib, the corticosteroid dexamethasone , or small interfering RNA (siRNA) knockdown of COX-2 expression.”
Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization.“Förster et al. report that the inhibition of stress-induced mesangial-cell apoptosis by dexamethasone is mediated by sphingosine-1-phosphate.”
“ Dex not only significantly alters the expression of the cytosolic isoenzyme sphingosine kinase 1 but also initiated an enhanced intracellular formation of the sphingolipid sphingosine 1-phosphate (S1P).”
“As preincubation with S1P reduced the number of apoptotic cells after stimulation with TNFα/actinomycin and moreover DEX increased the intracellular S1P content a role of this sphingolipid in the cytoprotection by DEX is suggested.”
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