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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Dexamethasone and Serine

supplement:

Serine

Research Papers that Mention the Interaction

Cotreatment with DEX blocked TNF induction of basal lipolysis and insulin resistance by antagonizing TNF stimulation of PKA-mediated phosphorylation of hormone-sensitive lipase (HSL) at Ser⁵⁶³ and Ser⁶⁶⁰ and perilipin.
American journal of physiology. Endocrinology and metabolism  •  2012  |  View Paper
Dexamethasone administration had a significant suppressive effect on plasma serine levels in depression but not in normal controls.
Neuropsychobiology  •  1995  |  View Paper
DEX …, serine , threonine and urea) and lipid metabolism-related products (palmitic acid, stearic acid and cholesterol) while decreasing the levels of β-hydroxy butyric acid, succinic … oxidation of fatty acids, and promoted the de novo synthesis of fatty acids as well as protein decomposition in the liver of broilers.
Journal of animal physiology and animal nutrition  •  2018  |  View Paper
The change to serine , a small polar amino acid (Tyr735Ser), caused significantly lower affinity for dexamethasone (10.4 nM).
Molecular endocrinology  •  1999  |  View Paper
Dexamethasone treatment increased serine and glutamine levels in conditioned medium and increased glutamate induced glutamine release suggesting an upregulation of glutamine synthase activity.
Brain Research  •  2003  |  View Paper