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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dexamethasone
supplement:
Serine
Research Papers that Mention the Interaction
“… DEX …, serine , threonine and urea) and lipid metabolism-related products (palmitic acid, stearic acid and cholesterol) while decreasing the levels of β-hydroxy butyric acid, succinic … oxidation of fatty acids, and promoted the de novo synthesis of fatty acids as well as protein decomposition in the liver of broilers.”
Glucose and lipid metabolism disorders in the chickens with dexamethasone‐induced oxidative stress“The change to serine , a small polar amino acid (Tyr735Ser), caused significantly lower affinity for dexamethasone (10.4 nM).”
Structure/function of the human glucocorticoid receptor: tyrosine 735 is important for transactivation.“Cotreatment with DEX blocked TNF induction of basal lipolysis and insulin resistance by antagonizing TNF stimulation of PKA-mediated phosphorylation of hormone-sensitive lipase (HSL) at Ser⁵⁶³ and Ser⁶⁶⁰ and perilipin.”
“ Dexamethasone administration had a significant suppressive effect on plasma serine levels in depression but not in normal controls.”
“ Dexamethasone treatment increased serine and glutamine levels in conditioned medium and increased glutamate induced glutamine release suggesting an upregulation of glutamine synthase activity.”
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