Possible Interaction: Dexamethasone and Selenium

“The selenium concentration in the meat of animals receiving organic selenium was higher ( P<0.001) than that of animals receiving sodium selenite, at all levels (0.3; 0.9 and 2.7 mg/kg DM).”

“Cu/Zn-SOD in muscle showed higher activity in high-Se-low-Mn diets but lower activity when both high Se and Mn were combined (Se×Mn P<0.05).”

“ Mn supplementation increased Mn concentration in longissimus thoracis et lumborum, but simultaneously reduced Se concentration (P<0.05).”

“These results suggested that the effects of DEX on Se concentrations were tissue dependent and that the higher plasma Se observed in DEX-treated groups might be explained by the release of tissue Se into plasma as plasma SeGPx.”

“ SE organ invasion was significantly reduced in chicks treated with either ILK alone or DEX + ILK compared to controls.”

“The rate of transcription of the TRHR gene, measured by a nuclear run-on assay, was increased 3.0 +/- 0.57-fold (mean +/- SE ) in cells treated for 12 h with 100 nM dexamethasone.”

“The addition of dexamethasone (2 X 10(-7) M) to the culture medium also inhibited I5'D activity by 46 +/- 6% (+/- SE ; n = 4 experiments; P less than 0.02), whereas insulin and epinephrine were without effect.”

“As for biomass production, Se reduced both FM and DM of all studied plants' roots.”