Possible Interaction: Dexamethasone and Resveratrol

“Furthermore, resveratrol showed synergistic cytotoxicity when combined with dexamethasone , fludarabine, and bortezomib.”

“Results Resveratrol induced the proliferation and inhibited apoptosis of osteoblasts in the presence of dexamethasone.”

“Thus, the vasculoprotective and neuroprotective effects of resveratrol may be beneficial in DM patients.”

“… dexamethasone –insulin (… by resveratrol , but not by glycine, as shown by decreased lipid contents, reduced diameters of lipid droplets, decreased protein abundances for peroxisome proliferator-activated receptor …/EBPα), as well as increased protein abundance of peroxisome proliferator-activated receptor coactivator-1α (PGC-1α), critical transcriptional factors that regulates adipogenesis.”

“Resveratrol did not significantly affect blood glucose levels and blood pressure; however, resveratrol attenuated cardiac dysfunction and hypertrophy in DM mice.”

“The catabolic effects of dexamethasone were prevented by resveratrol and the protective effects of resveratrol on dexamethasone-induced atrogin-1 and MuRF1 expression were abolished in myotubes transfected with SIRT1 siRNA.”

“Both MLF and RES significantly improved apparent digestibility of DM , OM, NDF, ADF, and nitrogen, but the effect of RES was significant (P < 0.05).”

“The use of resveratrol to treat patients with type 2 DM led to a decrease in the urinary excretion of o-Tyr and concomitantly led to an improvement in insulin signaling and insulin sensitivity.”