supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Dexamethasone
supplement:
Proline
Research Papers that Mention the Interaction
“… DEX …, proline , serine, threonine and urea) and lipid metabolism-related products (palmitic acid, stearic acid and cholesterol) while decreasing the levels of β-hydroxy butyric acid, … oxidation of fatty acids, and promoted the de novo synthesis of fatty acids as well as protein decomposition in the liver of broilers.”
Glucose and lipid metabolism disorders in the chickens with dexamethasone‐induced oxidative stress“The results indicated that dexamethasone reduced the relative collagen synthesis and collagen mRNA levels in HSFs and increased the total incorporation of proline into proteins, the latter effect being due to increased activity in the intracellular proline pool.”
Comparison of the effects of dexamethasone and 13-cis-retinoic acid on connective tissue biosynthesis in human skin fibroblasts“ Dexamethasone produced an approximate twofold increase in the incorporation of proline into collagenase-digestible protein (CDP) and noncollagen protein (NCP) in the cell layer and medium.”
“ Abstract Dexamethasone at concentrations of 1.5 × 10 −8 M and higher inhibited the incorporation of [ 14 C]-proline into proline and hydroxyproline-containing protein fractions of freshly-isolated bone cells.”
“Part of the increase noted in total protein synthesis and type IV collagen synthesis after dexamethasone was due to enhanced intracellular activity of proline.”
Comparison of the effects of retinoids and glucocorticosteroid on protein and type IV collagen synthesis in HT-1080 (human basement membrane forming fibrosarcoma) cells.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback