Possible Interaction: Dexamethasone and Polyunsaturated Fatty Acids

“In addition, we observed that PUFAs induced p53 protein expression in MM cells under dexamethasone administration.”

“In summary, these results suggest that PUFAs enhance dexamethasone sensitivity to MM cells through the p53/miR-34a axis with a likely contribution of Bcl-2 suppression.”

“In this study, we noted that ω-3 polyunsaturated fatty acids PUFAs ) enhanced the dexamethasone sensitivity of MM cells by inducing cell apoptosis.”

“We studied whether n-3 long-chain PUFA could prevent insulin resistance induced by dexamethasone (a glucocorticoid) in healthy human volunteers.”

“We determined that GR was associated with PPAR β and α under basal conditions, and that this association was disrupted when PUFA were added in combination with Dex.”

“ Polyunsaturated fatty acids have been shown to decrease the binding of [3H]dexamethasone to rat liver glucocorticoid receptors by mixed non-competitive inhibition, suggesting that these fatty acids interact at a site on the receptor different from the hormone binding site.”

“ Dexamethasone caused a significant increase in the microsomal content of polyunsaturated fatty acids (arachidonic and linoleic acid), which was accompanied by a decrease in content of monoenoic fatty acids (oleic and palmitoleic acid).”