Possible Interaction: Dexamethasone and Palmitic Acid

“… DEX treatment significantly increased the … lipid metabolism-related products ( palmitic acid , stearic acid and cholesterol) while decreasing the levels of β-hydroxy butyric acid, succinic acid and malic acid, demonstrating …, and promoted the de novo synthesis of fatty acids as well as protein decomposition in the liver of broilers.”

“Short and prolonged exposure to dexamethasone combined with palmitic acid resulted in increased expression of fatty acid transporters, which was subsequently reflected by excessive intracellular accumulation of triacylglycerols and ceramide.”

“Results show that palmitic acid fed at 2% of diet DM has the potential to increase yields of milk and milk fat, independent of production level without increasing body condition score or body weight.”

“In the heart, palmitic and oleic acid levels were higher after 4 h of Dex and decreased to control (CON) levels within 8 h. Measurement of polyunsaturated FAs demonstrated a drop in linoleic and gamma-linolenic acid, with an increase in arachidonic acid (AA) after acute Dex injection.”