Possible Interaction: Dexamethasone and Ovalbumin

“The TR to both methacholine and OVA in treated animals with dexamethasone and all concentrations of safranal were significantly decreased compared to S group (p < 0.01 to p < 0.001).”

“ Ovalbumin administration in immunized, but not in control, rats induced … time-dependent neutrophil accumulation, which was inhibited by dexamethasone , pentoxifylline or thalidomide, but not by selective inhibitors of nitric oxide (nitro-L-arginine), platelet-… (BN50730 or UK74505), prostaglandins (indomethacin), histamine (meclisine) or leukotriene B4 (MK 886 and CP105,696).”

“The glucocorticosteroid dexamethasone reduced all the parameters evaluated after Ova or after rmIL-13.”

“Prophylactic treatment with dexamethasone (1mg x kg (-1)) reduced the OVA induced AHR, eosinophilia and mucus cell hyperplasia/metaplasia measured 24h post challenge.”

“Therapeutic treatment, with dexamethasone (2 mg x kg(-1)), significantly inhibited established airway eosinophilia, measured at 72 h post OVA challenge, only when treatment was initiated at 24h but not 48 h after challenge.”

“Cell accumulation measured at 48 h after Ova injection was also significantly reduced (−75%) by Dex administration at the 24 h time‐point (n=12, P<0.05).”

“In immunized animals, gavage or voluntary ingestion of ovalbumin triggers an increase of vascular permeability in the intestine; pretreatment with a mixture of histamine and serotonin antagonists blocked this reaction, but not the aversion; dexamethasone inhibited both the aversion and the increase in permeability.”

“Delayed hypersensitivity reactions to OA were not modified by CsA, but were depressed by Dxt.”

“ OVA administration induced dose-dependent neutrophil migration, which was inhibited by pretreating the animals with dexamethasone , but not with indomethacin or BW 70C.”

“4 Dexamethasone (10 mg kg−1) inhibited oedema induced by ovalbumin (50 or 200 μg/paw, P < 0.05).”

“In the same way, protein and ovalbumin synthesis was inhibited and delayed by first intervention of DEX , and accelerated catabolism of ovalbumin and proteins was observed when DEX followed EB.”