Possible Interaction: Dexamethasone and Oleic Acid

“… dexamethasone , cortisol and corticosterone) and mineralocorticoids (deoxycorticosterone and aldosterone) as well as the … and the androgen testosterone enhanced the extent of Δ9 desaturation to oleic acid of the saturated precursors, whereas only the two mineralocorticoids affected the incorporation … exogenous acid into total cellular lipids, thus promoting a little stimulation.”

“30 min before oleic acid ) markedly reduced lung Evans blue content (to 0.24 +/- 0.04), as did pretreatments with prazosin (1 mg/kg), meloxicam (5 mg/kg) and dexamethasone (1 mg/kg/day, for 3 days).”

“In rat primary cultured hepatocytes, the addition of oleic acid suppressed reporter gene expression induced by dexamethasone in the construct containing the enhancer fragment of 714 bp with the AP-1 site, but not in its AP-1 site mutants or in 519 bp without the AP-1 site.”

“Further addition of oleic acid suppressed the induction of CPS and ASS mRNAs by dexamethasone.”

“In contrast, the phosphoenolpyruvate carboxykinase (PEPCK) mRNA level induced by dexamethasone was enhanced in the presence of oleic acid.”

“The AP‐1 DNA binding activity in the presence of dexamethasone was slightly enhanced by the addition of oleic acid.”

“Unsaturated fatty acids such as oleic (C18:1), arachidonic (C20:4) and docosahexaenoic acid (C22:4) depressed the [3H]R5020 or [3H]dexamethasone binding in increasing order, but saturated fatty acids had no effect.”

“ Dexamethasone caused a significant increase in the microsomal content of polyunsaturated fatty acids (arachidonic and linoleic acid), which was accompanied by a decrease in content of monoenoic fatty acids ( oleic and palmitoleic acid).”