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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Dexamethasone
supplement:
Niacin
Research Papers that Mention the Interaction
“Furthermore, the effect of dexamethasone on these genes, regarding both mRNA levels and the abundance of H3K4me3 and H3K9/14ac in their promoters, can be inhibited by the presence of nicotinamide , a metabolic molecule which has been shown to possess anxiolytic properties.”
The role of H3K4me3 and H3K9/14ac in the induction by dexamethasone of Per1 and Sgk1, two glucocorticoid [corrected] early response genes that mediate the effects of acute stress in mammals.“Here we present … the metabolite nicotinamide , an inhibitor of SIRT1, PARP-1 and …(ADP-ribosyl) transferases, blocks the ability of dexamethasone to induce the acute response of the circadian clock gene, mper1, while it concomitantly … the levels of histone H3 trimethylation of lysine 4 (H3K4me3) in the mper1 promoter.”
“A combination of nicotinamide or other pyridines with dexamethasone was shown to maintain ECD at or above the activity of untreated livers in vivo and to potentiate induction by xenobiotics.”
“ Nicotinic acid blocked the lipolytic effect of growth hormone plus dexamethasone , and theophylline potentiated their lipolytic action.”
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