Possible Interaction: Dexamethasone and Methionine

“ Dexamethasone increases the specific activity of alkaline phosphatase in a time‐ and dose‐dependent fashion (maximum 14‐fold induction at 10−6 M , IC50 = 10−8 M), and this induction can be completely inhibited by simultaneous incubation with picomolar concentrations of recombinant human IL‐1α or IL‐1β.”

“Autophagy markers (LC3-II and Beclin-1) were increased at the low dose of Dex (10−7 or 10−6 M ) and decreased at the high dose (10−5 M).”

“GW856553 (10−9 and 10−10 M ) synergistically increased the inhibitory effect of dexamethasone (10−8 and 10−6 M) on LPS-induced CXCL8 release in COPD.”

“The addition of dexamethasone to IL-1ß-stimulated chondrocytes further reduced the PG concentration by 19% at 10 -5 M and by 17% at 10 -7 M. The MMP-3 expression was inhibited between 27-53% and the AGG expression between 30-46% by dexamethasone.”

“The results showed that basal levels of ALP activity were expressed by all the cells and that DEX upregulated ALP levels in the M , RT and PL cells but not in the gingival cells.”

“A two‐fold increase in leptin release was detectable by 36 h of treatment with 10−7 M dexamethasone.”

“Co‐incubation of cells with dexamethasone (107 M) and insulin (10−7 or 10−9 M ) completely blocked the dexamethasone‐stimulated increase in ob mRNA and leptin release.”

“In line with these findings, the cAMP content of Ishikawa cells was decreased by 29.2% after a 15 min treatment with 10‐7 M dexamethasone (n = 4, P < 0.01).”

“A 48‐hour preincubation with 10−7 M dexamethasone markedly enhanced both the sensitivity and maximal effectiveness of IGF‐I stimulation of AIB uptake.”

“cultured with cytomix (p<0.05, all comparisons) and each was decreased by dexamethasone 10-6 M (p<0.05, all comparisons).”

“ Dexamethasone (10−9‐10−7 M) caused a dose‐dependent decrease in ecto‐NTP pyrophosphatase activity ( 10−7 M , p > 0.001); concentrations higher than 10−7 M did not evoke greater inhibition.”

“Interestingly, the stimulatory effect of 10−9 M 1,25(OH)2D3 on ecto‐NTP pyrophosphatase activity was significantly enhanced in the presence of dexamethasone (10−9‐10−7 M).”