Possible Interaction: Dexamethasone and Melatonin

“Mean melatonin levels decreased significantly after the administration of dexamethasone across all four groups.”

“A significant reduction was found between melatonin plasma levels before and after dexamethasone at 0400h (P < 0.01, t test for dependent groups).”

“It is suggested that dexamethasone affects nocturnal production of melatonin by means of mechanisms within the pineal gland.”

“A first group of 15 individuals with normal cortisol cycle (12·2 ± 1·4 at 0800 h and … h), and levels below 1·0 μg/100 ml after dexamethasone, showed a highly significant increase in melatonin … dexamethasone treatment (63·5 ± 5·5 ng/… the control night, P > 0·001).”

“KEY FINDINGS In the present study, we found that 100 μM De si gnificantly reduced osteoblast differentiation and mineralization in MC3T3-E1 cells and that 1 μM mel atonin at tenuated these inhibitory effects.”

“In chondrocytes, the pretreatment of melatonin reverses the extracellular matrix degradation induced by dexamethasone.”

“Meanwhile, the significant decrease in NAD+/NADH ratio and NADPH concentration in Dex group were up‐regulated by pretreatment of melatonin.”

“Melatonin alone have no effect on the quantity of proteoglycans and collagen type IIa1, however, the pretreatment of melatonin reversed the negative effects induced by Dex.”

“ Melatonin restores NAD+/NADH ratio and NADP concentration after the stimulation of dexamethasone.”

“We found that maternal melatonin therapy prevents postnatal dexamethasone (DEX)-induced programmed hypertension.”

“Our previous study found that melatonin , synthesized primarily in the pineal, pretreatment prevented the negative effects of dexamethasone , the glucocorticoid receptor agonist, on behavior and neurogenesis in rat hippocampus.”

“ Dex administration decreased antioxidant enzyme activities (…, CAT, GSH‐PX), plasma melatonin level and melatonin receptor (MT1) expression with a concomitant increase in lipid peroxidation (TBARS) and altered testicular histopathology which might culminate into increased germ cell apoptosis as evident from increased Bax/Bcl‐2 ratio and caspase‐3 expression.”

“Maternal melatonin therapy augmented renal Mas protein levels in DEX + melatonin group, and increased renal mRNA expression of HDAC-1, HDAC-2, and HDAC-8 in control and DEX offspring.”

“Reduced nephron numbers due to prenatal dexamethasone exposure were prevented by melatonin therapy.”

“Our results revealed that chronic administration of DEX induced depressive-like behavior and that this could be reversed by pretreatment with melatonin.”