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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dexamethasone
supplement:
Linoleic Acid
Research Papers that Mention the Interaction
“Our data showed that dexamethasone induced changes in bile and that linoleic acid clearly impaired the regulation exerted by the dexamethasone on bile lipids.”
Effects of Dexamethasone and Linoleic Acid on Hepatic Secretion of Biliary Lipids and Anionic Polypeptide Factor: In vivo and in vitro Studies“Treatment of rats with erythromycin or dexamethasone induced bisallylic hydroxylation of linoleic acid to 11-HODE in liver microsomes by 2- and 10-fold, respectively.”
“ Dexamethasone caused a significant increase in the microsomal content of polyunsaturated fatty acids (arachidonic and linoleic acid ), which was accompanied by a decrease in content of monoenoic fatty acids (oleic and palmitoleic acid).”
Glucocorticoids increase the fluidity of the fetal-rat liver microsomal membrane in the perinatal period.“On the other hand, the low-molecular-weight aldehyde fraction in secondary products of linoleic acid decreased phosphoglucomutase activity in hepatocytes cultured with dexamethasone.”
Hepatic Phosphoglucomutase Activity as a Marker of Oxidative Stress Induced by Pro-oxidative Drugs.
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