Possible Interaction: Dexamethasone and Leucine

“ Leucine , for example, can alleviate the effect of dexamethasone on muscle protein accretion.”

“Tryptophan and L -dopa loading was found to raise the sensitivity of the hypothalamo-pituitary complex to inhibition by dexamethasone.”

“Confirmation of PG G/H S-2 as the source of …-PGF2 alpha formation was obtained by down-regulating the enzyme with dexamethasone ; preventing protein synthesis with cycloheximide; and preventing synthesis of PGE2, TxB2, and …-epi-PGF2 alpha with the specific PG G/H S-2 inhibitor, L 745,….”

“Thymidine and uridine, but not leucine , incorporation into macromolecules or acetate incorporation into fatty acids were similarly inhibited by dexamethasone in the presence of absence of insulin.”

“ Leucine , at least partially, inhibited the effects of dexamethasone on protein synthesis via the mTOR pathway.”

“Steers fed L consumed 3.2% less DM than those fed H (linear, P < .05), resulting in 6.9% lower ADG (linear, P = .02) and 3.6% lower gain efficiency (linear, P < .15).”

“Corticosteroids such as dexamethasone (DEX) increase leucine turnover and oxidation in humans and animals, indicating whole body protein catabolism.”

“ DEX increased leucine turnover by 18± 14% (mean ± SD, p < 0.05), and oxidation by 132± 64% (p < 0.01) over baseline values.”

“ Dexamethasone increased the secretion of [3H]leucine in apolipoprotein (apo) E, and in the large (BH) and small (BI) forms of apo B in VLDL by about 7.1-, 3.6- and 4.0-fold respectively.”

“However, dexamethasone plus 2 nM-insulin increased the incorporation of [3H]leucine into apo AI, apo AH plus apo C, apo AIV and apo E of HDL by about 1.8-, 1.6-, 1.7- and 2.0-fold respectively.”

“The incorporation of [3H]leucine into lipoprotein lipase during incubations of rat epididymal fat-bodies in vitro was significantly stimulated by dexamethasone , whereas total protein synthesis was unaffected.”

“The glucocorticoid dexamethasone inhibits the activity of this transport system; the initial rates of sodium-independent uptake of leucine , phenylalanine, and 2-aminonorborane-2-carboxylic acid are decreased by approximately one-third (average = 30%, n = 19) after incubation of HTC cells with 0.1 microM dexamethasone.”