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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Dexamethasone and Indole-3-Carbinol

Research Papers that Mention the Interaction

While EROD activity was not inhibited in the presence of quercetin or indole-3-carbinol , significant and synergistic inhibition was detected when either of these was combined with clotrimazole or dexamethasone.
Chemosphere  •  2018  |  View Paper
In this study, we showed that, indole-3-carbinol (I3C), a natural product found in broadly consumed plants of the Brassica genus, could block the cytotoxic effects of dexamethasone (Dex), and elucidated the underlying molecular mechanisms.
Moreover, exposure to Dex triggered a rapid onset and time-dependent superoxide overproduction in osteoblastic cells, which was effectively suppressed by addition of I3C.
Taken together, I3C can reverse cytotoxicity of Dex through blocking ROS overproduction and enhancement of Nrf2 expression.
Treatment of the cells with Dex resulted in activation of caspase-3/-8/-9 and subsequent cleavage of PARP, which was also effectively blocked by co-incubation of I3C.
Biochemical and biophysical research communications  •  2015  |  View Paper