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Last Updated: 2 years ago

Possible Interaction: Dexamethasone and Glutathione

supplement:

Glutathione

Research Papers that Mention the Interaction

Dexamethasone depleted both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun).
Biochemical pharmacology  •  2000  |  View Paper
In the present study, we have demonstrated that dexamethasone treatment of A‐T lymphoblastoid cells increases the content of two of the most abundant antioxidants [ glutathione (GSH) and NADPH] by up to 30%.
The FEBS journal  •  2016  |  View Paper
Cellular treatment with the toxically high doses of the synthetic GC receptor agonist, dexamethasone (DEX) elicited marked decreases in the levels of glutathione and increases in ROS production, lipid peroxidation and cell death.
Neurochemistry International  •  2016  |  View Paper
Dexamethasone (3 μm) produced … the levels of GSH , decreased γ-GCS activity and γ-GCS-HS mRNA expression at 24 h. The increase in GSH levels, γ-GCS-HS … promoter activity, and AP-1 DNA binding produced by TNF-α were abrogated by co-treating the cells with dexamethasone.
Thus these data demonstrate that TNF-α and dexamethasone modulate GSH levels and γ-GCS-HS mRNA expression by their effects on AP-1 (c-Jun homodimer).
The Journal of Biological Chemistry  •  1999  |  View Paper
Dexamethasone (3 microM) exposure … the levels of GSH and gamma-GCS activity at 24-96 h. The activity of gamma-GT did not change after oxidant treatment; however, it …-96 h. Thus oxidants and dexamethasone modulate GSH levels and activities of gamma-GT and gamma-GCS by different mechanisms.
The American journal of physiology  •  1998  |  View Paper
Dexamethasone was found to decrease GSH , total antioxidant activity and testosterone levels, meanwhile treatment with onion extract normalised these levels.
Andrologia  •  2021  |  View Paper
In addition, hepatic glutathione peroxidase activity was reduced by DEX.
Redox report : communications in free radical research  •  2018  |  View Paper
Levels of a hepatic glutathione adduct derived from 1′,6‐dihydroxybenzbromarone were increased by pretreatment with dexamethasone.
Journal of biochemical and molecular toxicology  •  2017  |  View Paper
MDA was increased and antioxidants such as SOD, GSH and FRAP decreased significantly in DM (p<0.05).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2012  |  View Paper
While glutathione and fullerol both were able to antagonize the effects of dexamethasone , fullerol had a greater effect than glutathione.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society  •  2012  |  View Paper
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