Possible Interaction: Dexamethasone and Glutathione

“ Dexamethasone depleted both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun).”

“In the present study, we have demonstrated that dexamethasone treatment of A‐T lymphoblastoid cells increases the content of two of the most abundant antioxidants [ glutathione (GSH) and NADPH] by up to 30%.”

“Cellular treatment with the toxically high doses of the synthetic GC receptor agonist, dexamethasone (DEX) elicited marked decreases in the levels of glutathione and increases in ROS production, lipid peroxidation and cell death.”

“ Dexamethasone (3 μm) produced … the levels of GSH , decreased γ-GCS activity and γ-GCS-HS mRNA expression at 24 h. The increase in GSH levels, γ-GCS-HS … promoter activity, and AP-1 DNA binding produced by TNF-α were abrogated by co-treating the cells with dexamethasone.”

“Thus these data demonstrate that TNF-α and dexamethasone modulate GSH levels and γ-GCS-HS mRNA expression by their effects on AP-1 (c-Jun homodimer).”

“ Dexamethasone (3 microM) exposure … the levels of GSH and gamma-GCS activity at 24-96 h. The activity of gamma-GT did not change after oxidant treatment; however, it …-96 h. Thus oxidants and dexamethasone modulate GSH levels and activities of gamma-GT and gamma-GCS by different mechanisms.”

“ Dexamethasone was found to decrease GSH , total antioxidant activity and testosterone levels, meanwhile treatment with onion extract normalised these levels.”

“In addition, hepatic glutathione peroxidase activity was reduced by DEX.”

“Levels of a hepatic glutathione adduct derived from 1′,6‐dihydroxybenzbromarone were increased by pretreatment with dexamethasone.”

“MDA was increased and antioxidants such as SOD, GSH and FRAP decreased significantly in DM (p<0.05).”

“While glutathione and fullerol both were able to antagonize the effects of dexamethasone , fullerol had a greater effect than glutathione.”