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Last Updated: 4 months ago

Possible Interaction: Dexamethasone and Glutathione



Research Papers that Mention the Interaction

In the present study, we have demonstrated that dexamethasone treatment of A-T lymphoblastoid cells increases the content of two of the most abundant antioxidants [ glutathione (GSH) and NADPH] by up to 30%.
The FEBS journal  •  2016  |  View Paper
Cellular treatment with the toxically high doses of the synthetic GC receptor agonist, dexamethasone (DEX) elicited marked decreases in the levels of glutathione and increases in ROS production, lipid peroxidation and cell death.
Neurochemistry International  •  2016  |  View Paper
Dexamethasone (3 microM) produced … the levels of GSH , decreased gamma-GCS activity and gamma-GCS-HS mRNA expression at 24 h. The increase in GSH levels, gamma-GCS-HS … promoter activity, and AP-1 DNA binding produced by TNF-alpha were abrogated by co-treating the cells with dexamethasone.
Thus these data demonstrate that TNF-alpha and dexamethasone modulate GSH levels and gamma-GCS-HS mRNA expression by their effects on AP-1 (c-Jun homodimer).
The Journal of biological chemistry  •  1999  |  View Paper
Dexamethasone (3 microM) exposure … the levels of GSH and gamma-GCS activity at 24-96 h. The activity of gamma-GT did not change after oxidant treatment; however, it …-96 h. Thus oxidants and dexamethasone modulate GSH levels and activities of gamma-GT and gamma-GCS by different mechanisms.
The American journal of physiology  •  1998  |  View Paper
Dexamethasone (3 μM) exposure … the levels of GSH and γ-GCS activity at 24-96 h. The activity of γ-GT did not change after oxidant treatment; however, it …-96 h. Thus oxidants and dexamethasone modulate GSH levels and activities of γ-GT and γ-GCS by different mechanisms.
American journal of physiology. Lung cellular and molecular physiology  •  1998  |  View Paper
Dexamethasone depleted both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun).
Biochemical pharmacology  •  2000  |  View Paper
Levels of a hepatic glutathione adduct derived from 1',6-dihydroxybenzbromarone were increased by pretreatment with dexamethasone.
Journal of biochemical and molecular toxicology  •  2017  |  View Paper
While glutathione and fullerol both were able to antagonize the effects of dexamethasone , fullerol had a greater effect than glutathione.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society  •  2012  |  View Paper
The systemic administration of DEX led to a significant increase in the total GSH level in the cochlea 2 to 24 h later.
Brain Research  •  2006  |  View Paper
The combined treatment with dexamethasone and UVB induced large reductions in the concentration of reduced glutathione , inositols, taurine and lactate compared with normal lenses.
Graefe's Archive for Clinical and Experimental Ophthalmology  •  2004  |  View Paper
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