Possible Interaction: Dexamethasone and Glucose

“After 2 days of dexamethasone treatment, whole body insulin‐mediated glucose disposal was decreased by 40·8%.”

“… glucose … dexamethasone than in those who received placebo (glucose, 2.0 vs. 0.4 mmol per liter [36.0 vs. 6.9 mg per deciliter], P …; and protein, 0.64 vs. 0.25 g per liter [64.0 vs. 25.3 mg per deciliter], P less than 0.05).”

“… DEX … glucose , intermediates in protein metabolism (valine, proline, serine, threonine and urea) and lipid metabolism-related products (palmitic acid, stearic acid and cholesterol) while decreasing the … oxidation of fatty acids, and promoted the de novo synthesis of fatty acids as well as protein decomposition in the liver of broilers.”

“Thus, liver weight and fetal and maternal cortisol, glucose , and insulin levels were significantly influenced by the multiple administration of dexamethasone.”

“The effect of glucose was additive with that of dexamethasone , which induces GH receptors.”

“Furthermore, one has to keep in mind that dexamethasone induces a mild increase in glucose.”

“Furthermore, one has to keep in mind that dexamethasone induces a mild increase in glucose.”

“We found that dexamethasone treatment significantly increased the following fasting serum levels (P<0.05): HDL, LDL, total cholesterol, triglycerides, glucose , and insulin.”

“ Dexamethasone administration (given in 406 [44.7%] patients) was a risk factor for glucose increase (P<0.001).”

“ Dexamethasone treatment in both study groups increased homeostasis model assessment of insulin resistance and AUC glucose and decreased the Matsuda index (P = .001).”