Possible Interaction: Dexamethasone and Genistein

“ Genistein acts synergistically with drugs such as tamoxifen, cisplatin, 1,3-bis 2-chloroethyl-1-nitrosourea (BCNU), dexamethasone , daunorubicin and tiazofurin, and with bioflavonoid food supplements such as quercetin, green-tea catechins and black-tea thearubigins.”

“In a select set of genes, co-regulation by dexamethasone and genistein was found to require both GR and ERα signaling, respectively.”

“Results: Genistein regulated numerous genes in Ishikawa cells independently of estradiol, and the response to coadministration of genistein and dexamethasone was unique compared with the response to either estradiol or dexamethasone alone.”

“The combined effects of dexamethasone and genistein on the induction of p21 protein and activation of p21 promoter were synergistic in both cell lines.”

“These findings indicate that dexamethasone and genistein act in a synergistic fashion and have potential for combination chemotherapy for the treatment of liver and colon cancer.”

“ Genistein inhibited lipid accumulation and decreased the nonesterified fatty acid (NEFA) content of 3T3‐L1 on day 6 after the induction of differentiation with methylisobutylxanthine, dexamethasone and insulin (MDI).”

“In both rats and humans, when dexamethasone was added to the bone-forming medium, genistein (10(-7) M and 10(-8) M) caused a significant increase in the levels of calcium, alkaline phosphatase, and DNA compared with cells not cultured in genistein.”

“The TE-R2.5-mediated BWRT8 apoptosis was suppressed by Na-orthovanadate, an inhibitor of protein tyrosine phosphatases (PTP) as well as by genistein , a protein tyrosine kinase (PTK) inhibitor, while both compounds potentiated the effect of Dx.”

“It is concluded that the synergistic actions of genistein and dxm , and of genistein + sodium azide in induction of apoptosis and/or necrosis may be of clinical and pathophysiological research interest considering the chemopreventive and chemotherapeutic potential of genistein; and the clinico‐pharmacological application of dexamethasone and sodium azide.”

“The results from the data obtained demonstrated: i) that incubation of testis cells with each of the agents (Gn, … dexamethasone mostly and significantly induced apoptotic cell death while sodium azide induced necrotic cell death; iii) that addition of dexamethasone … genistein demonstrated synergism in apoptosis on … not induce significant necrosis.”

“Induction of activity, message, and protein by either agent was blocked by 1 μM dexamethasone and attenuated by genistein (100 μM), a nonspecific tyrosine kinase inhibitor.”

“In contrast, the mRNA and protein expression of Eph B4 and ephrin B2 were increased in mice treated by DXM with genistein as compared to the DXM single treatment.”

“The treatment of DXM group with genistein significantly elevated the ratio of OPG/RANKL.”