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Possible Interaction: Dexamethasone and Arachidonate

Research Papers that Mention the Interaction

These data suggest that a unique inflammatory mediator network regulates CRIg expression and point to a mechanism by which arachidonate and dexamethasone have reciprocal effects on inflammation.
The American journal of pathology  •  2011  |  View Paper
Dexamethasone treatment (1-100 nM for 20 h), which was earlier shown to dose-dependently down-regulate the 85 kDa phospholipase A2 and its activation by phorbol ester and zymosan, was here shown also to counteract the protein kinase C-independent activation and arachidonate release elicited by bacteria.
The Biochemical journal  •  1997  |  View Paper
This occurs because DEX inhibits the IL-1-induced enhanced arachidonate release.
The American journal of physiology  •  1992  |  View Paper
Our results suggest a possible link between arachidonate metabolites inhibited by indomethacin or dexamethasone and the genesis of cytochrome P-450 disfunction.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology  •  1991  |  View Paper
Arachidonate and other long-chain fatty acids appear to inhibit the … ([3H]R2858), progestin ([3H]R5020), androgen ([3H]R1881) and glucocorticoid ( [3H]dexamethasone ) to the respective receptors in brain (neonatal cerebral cortex and hypothalamus-preoptic area, … prostate, with the exception of the potentiating effect on the brain estrogen receptors.
Journal of steroid biochemistry  •  1989  |  View Paper
In contrast, arachidonate release was inhibited in dexamethasone treated macrophages.
Biochemical and biophysical research communications  •  1988  |  View Paper
Inhibition of phospholipase A2 with para-bromophenacyl bromide, dexamethasone or quinacrine, alone or in combination, blocked arachidonate release by 50%-60% but had no effect on EDRF production as assessed by cyclic GMP accumulation in mixed- or co-cultures of endothelial and vascular smooth muscle cells.
The American journal of the medical sciences  •  1988  |  View Paper
Protection was obtained by FPL 55712, a selective antagonist of sulfidopeptide leukotrienes, by diethylcarbamazine, an inhibitor of leukotriene biosynthesis, by BW 755C, a dual lipoxygenase and cyclooxygenase inhibitor, and by dexamethasone , which inhibits arachidonate release.
Circulatory shock  •  1984  |  View Paper
Dexamethasone at a dose of 6 mg.kg-1 given to rabbits for three days prior to challenge with sodium arachidonate (2 mg.kg-1) intravenously, improved survival from 0% to 90% (p less than 0.01).
Dexamethasone , given for shorter periods prior to arachidonate injection resulted in survival rates from 17% to 40%.
Prostaglandins  •  1981  |  View Paper
Dexamethasone and the other inducers stimulated the release of arachidonate from phospholipids.
Journal of cellular physiology  •  1980  |  View Paper