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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Dexamethasone
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“ Alpha-ketoglutarate administered to … influence of dexamethasone lowered the total cholesterol concentration by 40%, and enhanced aspartate by 41%, serine by 76%, glutamate by 105%, glutamine by 36%, … arginine by 105%, as well as methionine and cystathionine, but increased the sulphur concentration compared with the control (p < 0.01).”
“Postnatal administration of AKG had a protective effect on liver structure, and lowered the total cholesterol concentration in piglets prenatally exposed to dexamethasone , and also influenced selected macro- and microelement serum concentrations and amino acids plasma concentration.”
Alpha-ketoglutarate protects the liver of piglets exposed during prenatal life to chronic excess of dexamethasone from metabolic and structural changes.“Simultaneous administration of Dex and AKG significantly increased the analyzed properties of humeri.”
“ Dexamethasone treatment produced significant decreases in the lung concentrations of glutamine (47.2%), glutamate (30.9%) and 2-oxoglutarate (57.3%).”
“ Dexamethasone treatment produced significant decreases in the concentrations of skeletal muscle glutamine (51.8%) and 2-oxoglutarate (50.8%).”
“ Dexamethasone phosphate causes approximately a threefold increase of the tyrosine-alpha-ketoglutarate transaminase in the culture of RLC cells.”
[The importance of the substrate for the induction of tyrosine-alpha-ketoglutarate-transaminase in RLC-cells (author's transl)].
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