Possible Interaction: Dexamethasone and Adrenocorticotropic Hormone

“Prospective reversal of resistance at progression by adding dexamethasone 0.5 mg/d to suppress adrenocorticotropic hormone and upstream steroids was pursued.”

“Valproic acid decreased moderately ACTH concentration in two patients, while following dexamethasone administration a fall in ACTH levels was observed in all three patients, the most evident in the patient with a non-invasive Nelson's adenoma.”

“Stepwise multiple regression analysis revealed that both percent cortisol and percent ACTH variations were significantly and negatively influenced by dexamethasone levels, as well as by waist circumference values in men, and independently by BMI and waist circumference in women.”

“ Dexamethasone administration suppressed ACTH and the aldosterone response to calcium but did not affect the PRA response to the calcium infusion.”

“Blood levels of ACTH , beta-endorphin, cortisol, and cortisol-binding globulin were lowered by Dex at rest and after exercise.”

“The site of HPA suppression was located to the pituitary gland as the mean basal ACTH level dropped from 9.5 +/- 5.2 pmol/l to 5.6 +/- 2.0 pmol/l after the dexamethasone course.”

“This study is the first to demonstrate the parallel inhibition by DEX of ACTH and cortisol responses to CRH and VIP in Cushing's disease.”

“ Dexamethasone was given to suppress adrenal corticotrophic hormone.”

“In another group of volunteers, secretion of adrenocorticotropin (ACTH), hence of cortisol, was completely suppressed with dexamethasone while the men were receiving placebo and again during a perior of lithium medication.”

“A single patient became normotensive on prolonged dexamethasone suppression of ACTH and 18-OH-DOC secretion.”