Possible Interaction: Desipramine and Yohimbine

“A pharmacodynamic and pharmacokinetic interaction between yohimbine and clomipramine or demethylclomipramine was discussed.”

“Neither desipramine nor desipramine-yohimbine proved to be an effective treatment, although concomitant yohimbine administration did attenuate the ability of desipramine to decrease plasma free and 24-hour urinary 3-methoxy-4-hydroxyphenyl-ethyleneglycol levels and blood pressure.”

“Pretreatment with desipramine abolished DHPG responses to yohimbine while enhancing NE responses.”

“Addition of yohimbine prevented the depressant effect of desipramine on the EJCs completely and reduced that of cocaine, but increased their effects on the Δ[NA]CF response.”

“In contrast, desipramine augmented the effect of yohimbine on brain MHPG levels resulting in a shift to the left of the dose response curves.”

“ Desipramine (2 mg/kg), a selective noradrenaline reuptake blocker, reduced the … stimulation; this effect was reversed by the α2-adrenoceptor antagonists yohimbine (0.5 mg/kg) and (-)mianserin (0.5 mg/kg), but not by idazoxan (… mg/kg), an adrenoceptor antagonist with preferential affinity for the imidazoline recognition sites.”

“In the presence of desipramine, yohimbine (0.1–1 μmol/l) increased the number of e j.cs even more markedly.”

“After desipramine treatment, yohimbine further enhanced the SNS-induced increases in EPI and NE output.”

“After yohimbine treatment, desipramine further enhanced the SNS-induced increase in NE output.”

“… yohimbine (10(-7) M, an alpha 2-adrenoceptor antagonist), …-adrenoceptor antagonist), and two catecholamine uptake inhibitors, desipramine (10(-7) M) and normetanephrine (10(-6) M), the maximum responses to NA were decreased in … PVL rats: 45% decrease in portal vein, 25% in mesenteric artery and 18% in tail artery.”

“In the presence of desipramine , nerve stimulation induced a frequency-dependent increase in NA overflow and postsynaptic response, both were enhanced by yohimbine.”