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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Desipramine
supplement:
Tryptophan
Research Papers that Mention the Interaction
“Both desipramine (N = 7) and amitriptyline (N = 6) significantly increased the PRL rise induced by tryptophan compared with a preceding placebo period.”
Serotonin function and mechanism of action of antidepressant treatment. Effects of amitriptyline and desipramine.“When combined with tryptophan , fluoxetine augmented and DMI diminished the effects of tryptophan on all behaviors.”
Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems“Acute and chronic administration of … major metabolite desmethylimipramine DMI) … brain tryptophan concentration, thereby enhancing cerebral 5-hydroxytryptamine (5-HT) synthesis, by increasing the availability of circulating tryptophan to the brain, … of liver tryptophan pyrrolase (tryptophan 2,3-dioxygenase, L-tryptophan:O2 oxidoreductase, decyclizing; EC 1.13.11.11) activity.”
“In addition, desipramine increased the ratio of brain Trp to plasma free Trp of the runners.”
“The increase in brain tryptophan concentration caused by administration of mianserin, viloxazine, desipramine or tranylcypromine is associated with an accumulation of tryptophan in the liver and an increased availability of the circulating amino acid to the brain.”
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