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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Desipramine and Tryptophan

supplement:

Tryptophan

Research Papers that Mention the Interaction

Both desipramine (N = 7) and amitriptyline (N = 6) significantly increased the PRL rise induced by tryptophan compared with a preceding placebo period.
Archives of general psychiatry  •  1984  |  View Paper
When combined with tryptophan , fluoxetine augmented and DMI diminished the effects of tryptophan on all behaviors.
Psychopharmacology  •  2005  |  View Paper
Acute and chronic administration of … major metabolite desmethylimipramine DMI) … brain tryptophan concentration, thereby enhancing cerebral 5-hydroxytryptamine (5-HT) synthesis, by increasing the availability of circulating tryptophan to the brain, … of liver tryptophan pyrrolase (tryptophan 2,3-dioxygenase, L-tryptophan:O2 oxidoreductase, decyclizing; EC 1.13.11.11) activity.
Biochemical pharmacology  •  1991  |  View Paper
In addition, desipramine increased the ratio of brain Trp to plasma free Trp of the runners.
British journal of pharmacology  •  1985  |  View Paper
The increase in brain tryptophan concentration caused by administration of mianserin, viloxazine, desipramine or tranylcypromine is associated with an accumulation of tryptophan in the liver and an increased availability of the circulating amino acid to the brain.
Biochemical pharmacology  •  1981  |  View Paper