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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Desipramine
supplement:
Progesterone
Research Papers that Mention the Interaction
“Imipramine, desipramine , mazindol, and GBR12909 competitively inhibited PROG 21-hydroxylation mediated by CYP2D4 and/or CYP2D6, and all psychotropic drugs inhibited ALLO 21-hydroxylation mediated by CYP2D4 and/or CYP2D6.”
“The inhibition constants (Ki values) of imipramine, desipramine , and mazindol against the 21-hydroxylation of PROG and ALLO by CYP2D6 were lower than those by CYP2D4.”
Effect of psychotropic drugs on the 21-hydroxylation of neurosteroids, progesterone and allopregnanolone, catalyzed by rat CYP2D4 and human CYP2D6 in the brain.“Both, progesterone (0.5 mg/rat) and estradiol benzoate (4.0 micrograms/rat) were able to decrease the cumulative burying behavior when injected with a subthreshold dose of DMI (1.25 mg/kg).”
“In addition, the effect of DMI (1.25 mg/kg) plus the combination of estradiol benzoate and progesterone , sequentially administered (48 h and 4 h before the tests, respectively), also produced a synergistic decrease in burying behavior.”
“It is concluded that DMI synergizes its anxiolytic-like effect when administered with estradiol alone or in combination with progesterone.”
Interaction of desipramine with steroid hormones on experimental anxiety
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