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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Desipramine and Oxytocin

drug:

Desipramine

supplement:

Oxytocin

Research Papers that Mention the Interaction

“ DMI decreased oxytocin content of the hypothalamus and neurointermediate lobe in non operated and sham-operated animals.”
The hypothalamic and neurohypophysial oxytocin content as influenced by desmethylimipramine in normal and pinealectomized white male rats
Journal of Neural Transmission  •  2005  |  View Paper
“Fluoxetine and DMI potentiated the MK-212- and DOI-induced increase of plasma oxytocin levels and potentiated the effect of DOI on plasma adrenocorticotropic hormone (corticotropin) and prolactin levels.”
Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI).
The Journal of pharmacology and experimental therapeutics  •  1993  |  View Paper
“It may be supposed that chronic treatment with DMI inhibits the oxytocin release from neurohypophysis.”
Chronic treatment with desmethylimipramine increases the oxytocin content in the hypothalamus and neurohypophysis of normal and pinealectomized male rats.
Acta physiologica Polonica  •  1988  |  View Paper