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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Desipramine
supplement:
Methionine
Research Papers that Mention the Interaction
“ Desipramine (DMI), at a concentration of 10−5 M , caused a 4-fold shift of the DA curve to th right.”
Direct and indirect actions of dopamine on tracheal smooth muscle“Tricyclic antidepressants nortriptyline, chlorimipramine, protiptyline, imipramine and desipramine at a concentration of 10−3 M caused 60–80% inhibition of PDE activity.”
“An exposure of 10 min to 10−7 M desipramine caused a leftward shift and an increase in the maximum response of cumulative dose-response curves of noradrenaline.”
“In vitro, desipramine and other antidepressants also inhibited in a concentration‐dependent manner (10−9 − 10−5 M ) the twitch responses.”
“2 Amitriptyline, nortriptyline, protriptyline, desipramine and imipramine were found to inhibit ATPases at concentrations of 10−5 m and above.”
“At 10−5 M DMI decreased the maximum response.”
“ DMI in concentrations of 5 x 10-7, 10-6 and 5 x 10-6 M progressively inhibited norepinephrine (NE)-induced contractions, decreasing both the maximum and the slope of the log dose-response curve.”
“4 The administration of desipramine (DMI, 20 mg/kg intraperitoneally) 1 hr after M (100 μg/kg intravenously) induced a rapid sustained efflux of M from heart and salivary gland.”
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