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Naunyn-Schmiedeberg's Archives of Pharmacology • 2004 | View Paper
“Tricyclic antidepressants nortriptyline, chlorimipramine, protiptyline, imipramine and desipramine at a concentration of 10−3 M caused 60–80% inhibition of PDE activity.”
“An exposure of 10 min to 10−7 M desipramine caused a leftward shift and an increase in the maximum response of cumulative dose-response curves of noradrenaline.”
British journal of pharmacology • 1979 | View Paper
“ DMI in concentrations of 5 x 10-7, 10-6 and 5 x 10-6 M progressively inhibited norepinephrine (NE)-induced contractions, decreasing both the maximum and the slope of the log dose-response curve.”
The Journal of pharmacology and experimental therapeutics • 1970 | View Paper
“4 The administration of desipramine (DMI, 20 mg/kg intraperitoneally) 1 hr after M (100 μg/kg intravenously) induced a rapid sustained efflux of M from heart and salivary gland.”