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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Desipramine
supplement:
Melatonin
Research Papers that Mention the Interaction
“Acute administration of the noradrenaline uptake inhibitor, desipramine (DMI) (100 mg at 16.00 h), increased evening plasma melatonin concentrations.”
“The stimulatory effect of DMI on plasma melatonin was mirrored by increased urinary 6-sulphatoxymelatonin (aMT6s) excretion.”
Comparison of the effects of acute fluvoxamine and desipramine administration on melatonin and cortisol production in humans.“Acute administration of the antidepressant drug desipramine DMI ) in man, increased evening melatonin secretion, which reached peak plasma levels 2-4 h earlier than after placebo administration.”
“In depressed patients melatonin secretion was increased after three weeks' treatment with desipramine.”
“In normal volunteers the secretion of melatonin was increased by the noradrenaline uptake inhibitors desipramine and (+)-oxaprotiline; (-)-oxaprotiline had no effect.”
“There was also a significant negative correlation between 6-sulphatoxy melatonin levels and symptom severity as measured by the Hamilton Rating Scale for Depression after 3 weeks of treatment with desipramine.”
“Reduction in the normal nocturnal peak is found in depressed patients and there is an increase in nocturnal melatonin levels found in patients during treatment with desipramine.”
“Exogenous melatonin (0.25mg/kg/day) for 8 days counteracted the inhibitory effects of both desipramine and fluoxetine at concentrations of 2.5mg/kg/day.”
Influence of the antidepressants desipramine and fluoxetine on tryptophan-2,3-dioxygenase in the presence of exogenous melatonin.“Pineal melatonin content after daytime swimming exhibited a weak rise, unless DMI was injected, in which case melatonin levels showed a highly significant increase.”
“ DMI also potentiated the effect of NE (each 10−6 M) on melatonin accumulation in the medium of incubated hamster pineals taken after a short light exposure at night.”
“Repeated administration of either desmethylimipramine or nialamide reduced significantly the elevation in melatonin concentrations in the pineal gland produced by either L-isoproterenol or darkness.”
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