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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Desipramine
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“The inhibitory effect of GABA was facilitated by concurrent application of desipramine , carbamazepine or diazepam at a concentration of 5 x 10(-5)-2 x 10(-4) M. The rank of order of facilitation is: desipramine > carbamazepine > diazepam.”
Involvement of GABAergic systems in manifestation of pharmacological activity of desipramine.“Both compounds substantially attenuated the enhancement of the inhibitory responses to GABA produced by NE, with MDL 26,479 having a more marked effect than DMI.”
“A decreased efficacy of NE action after DMI pretreatment was manifested in both a higher mean iontophoretic current dose of the catecholamine required to induce threshold depressions of Purkinje cell spontaneous activity and a markedly diminished ability of NE to enhance inhibitory responses to gamma-aminobutyric acid.”
“Added to the perfusion medium at a concentration of 10 μmol L‐1, DMI caused a 5‐ to 10‐fold increase in the release of GABA.”
“Pargyline and desipramine increased the brain concentration of GABA but were without effect on GABA production.”
“Abstract In mice, intraperitoneal administration of desipramine (12·5–100 mg/kg) or pargyline (25–200 mg/kg) reliably elevated the brain concentration of gamma-aminobutyric acid in a dose-dependent manner.”
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