supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Desipramine
supplement:
Dextroamphetamine
Research Papers that Mention the Interaction
“Pretreatment with the selective noradrenergic uptake inhibitors nisoxetine and desipramine antagonized the locomotor stimulant effect of d-amphetamine without reducing the drug's stereotypy-inducing action.”
Norepinephrine uptake inhibitors as biochemically and behaviorally selective antagonists of the locomotor stimulation induced by indirectly acting sympathomimetic amines in mice“Chronic but not acute administration of DMI potentiated the locomotor response to d-amphetamine within a narrow dosage range.”
“At concentrations above 1 μmol/l, desipramine additionally caused an inhibition of the sodium-independent permeation of 3H (+)-amphetamine into PC-12 cells.”
“The sodium-sensitive component of uptake and accumulation of 3H (+)-amphetamine was fully inhibited by cocaine and desipramine.”
The transport of (+)-amphetamine by the neuronal noradrenaline carrier“Our results demonstrated that a single large dose administration of AMPH with desipramine elicited a delayed production of NO and concomitant long-term DA loss in the striatum.”
“For example, chronic administration of tricyclic antidepressant drugs such as imipramine and desipramine (DMI) enhances the locomotor stimulant effects of d-amphetamine.”
“In accordance with previous reports, the locomotor stimulant effects of d-amphetamine were also enhanced in the chronic DMI groups.”
“Repeated administration of DMI also enhanced d-amphetamine-induced locomotor hyperactivity.”
“EGYT-2760 and D-amphetamine enhanced the K+-induced 3H-noradrenaline overflow too, however this effect of D-amphetamine was abolished in the presence of cocaine and desipramine , while the effect of EGYT-2760 remained unaffected.”
“It was found that in normal … release of NA evoked by (+)-amphetamine (5 X 10(-6) M) or …) was antagonized by imipramine methiodide and desipramine , inhibitors of the NA uptake, but was not dependent on the presence … medium and was not antagonized by the potent local anaesthetic agent bethoxycaine.”
“ d-Amphetamine produced 20 and 67% desipramine lever selection at 0.64 and 1.25 mg/kg respectively.”
“(+)-Amphetamine, low external Na+, high external K+ and ouabain caused a pronounced increase in the … 37 degrees C but was almost without effect at 0 degrees C. The efflux evoked by (+)-amphetamine , low Na+ and … inhibited by desipramine , imipramine methiodide and cocaine, whereas millicaine … lidocaine had very poor effects.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback