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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Desipramine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“The stimulatory effects of desipramine and calcium on PKC activity in platelets appear to be occurring by the same mechanism.”
Effect of the tricyclic antidepressant desipramine on protein kinase C in rat brain and rabbit platelets in vitro“Again, in contrast to the hypothalmus, the removal of calcium from the medium markedly reduced "spontaneous" efflux of catecholamine and the desipramine induced efflux of NE, but not the increase in striatal DA efflux produced by desipramine.”
“The results suggest that the relaxation of the depolarized artery produced by desipramine may be due to interference with the action of calcium in initiating and maintaining a contraction of the arterial smooth muscle.”
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