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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Desipramine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Desipramine DMI ), a tricyclic antidepressant and norepinephrine (NE) reuptake blocker, is reported to induce ACTH and cortisol release acutely in humans, probably by facilitating central NE neurotransmission.”
“This is the first human study to suggest an inhibitory effect of DMI on central noradrenergic control of ACTH release.”
The effect of desipramine on basal and naloxone-stimulated cortisol secretion in humans: interaction of two drugs acting on noradrenergic control of adrenocorticotropin secretion.“Five weeks of treatment with desipramine (15 mg/kg) significantly reduced evening levels of both ACTH and corticosterone in all groups, and eliminated the group differences.”
Antidepressants Restore Hypothalamic-Pituitary-Adrenal Feedback Function in Aged, Cognitively-Impaired Rats“ DMI treatment augmented both the prolactin and ACTH responses to 8-OH DPAT in the SAL controls.”
“In slices of n. accumbens, but not in slices of striatum of rats exposed to the combined treatment of ACTH and DMI , a significant decrease in the inhibitory effect of exogenous DA on stimulated release of [3H]DA was observed.”
“This behavioural evidence indicates that ACTH potentiation involves a central mechanism and demonstrates a functional interaction between ACTH and DMI at the behavioural level.”
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