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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Deoxycholate
supplement:
Phosphatidylserine
Research Papers that Mention the Interaction
“In Caco2 cells, … addition of DOC (0·5 mM) induced, after 1 min, … increase in cell conductance of 583 ± 16 pS pF−1 (N= 8) which was reduced to 560·4 ± 16 pS pF−1 (…= 8) by DIDS (0·5 mM) and N‐phenylanthranilic acid (DPC; 0·5 mM).”
Activation of Ionic Channels by Deoxycholate in Frog and Human Cell Lines“Chenodeoxycholate and deoxycholate also caused an approximately 1.3-fold enhancement of PKC activity in the presence of 12-O-tetradecanoyl phorbol 13-acetate (TPA) and PS , and the absence of added Ca2+.”
“Chenodeoxycholate and deoxycholate appear to inhibit PKC by interactions with both Ca2+ and PS , since their inhibitory potencies are reduced at an elevated PS concentration and since both of these bile acids actually enhance PKC activity, approximately 2-fold, when assayed at an elevated Ca2+ concentration (2 mM).”
The regulation of protein kinase C by chenodeoxycholate, deoxycholate and several structurally related bile acids.“Incubation of the homogenates under various conditions revealed that deoxycholate inhibited phospholipase A activity and stimulated a phospholipase C activity in these cells which preferentially degraded phosphatidylinositol (PI) compared to phosphatidylcholine (PC), -ethanolamine (PE), and -serine ( PS).”
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