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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Deoxycholate
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Calcium concentration, faecal pH and deoxycholic acid concentration increased in the calcium group (p = 0.02, 0.005 and 0.004 respectively).”
Effect of calcium supplementation on mucosal cell proliferation in high risk patients for colon cancer.“The lysis induced by 1 mM deoxycholate in the presence of calcium was reduced by 80% in quin-2-loaded cells compared to controls.”
“The sensitivity of … effect of calcium in … mM deoxycholate increased with the length of time of their storage at 4 degrees C. The sensitivity returned to that of fresh … 37 degrees C with 30 mM adenosine plus 25 mM glucose, but this treatment did not further diminish the lysis.”
“In contrast, simultaneous addition of 2 mM calcium and 2 mg/ml sodium deoxycholate promoted the formation of IP3 and IP2, indicating phosphodiesteratic cleavage of PIP2 and PIP.”
“Steady-state clearances of sodium, potassium, calcium , chloride, and creatinine were increased (P < 0.05) by 2 mM deoxycholate.”
Deoxycholate effects on plasma solute clearance by gut perfusion in dog.“We characterized the cytosolic PLA2 enzyme with respect to substrate specificity, sensitivity …. We found that phosphatidylethanolamine, rather than phosphatidylcholine, was the preferred substrate, the Ca2+ ion was essential for the expression of PLA2 activity, the … range, with the optimum at pH 9.0, and sodium-deoxycholate inhibited the … manner.”
“Combined culture supernatant and deoxycholate reduced calcium uptake by 39% (p less than 0.001) suggesting a potentiation of supernatant activity by deoxycholate.”
“ Deoxycholate reduced calcium uptake by 16% (p less than 0.001).”
“The damaging … 5 mM deoxycholic acid to the colonic epithelium is inhibited by lowering the pH of … fluid from 7.9 to 5.5, or by increasing the calcium concentration from 0 to 4 mM. This inhibition is shown … because of a decreased amount of bile acid in solution.”
“Treatment of membranes with the detergents Triton X-100 or sodium deoxycholate resulted in a dose-dependent reduction in [3H]glutamate binding accompanied by a loss of the stimulatory effect of calcium ions.”
“A deoxycholate concentration exceeding 0.6 mM inhibited Ca 2 + -ATPase at any concentration of Ca 2+ .”
“ Deoxycholate affected the activity of Ca 2 + -ATPase at lower concentrations than caused turbidity of Ca 2+ -ATPase.”
“Sodium and potassium ions decreased Ca 2 + -ATPase activity in the presence of deoxycholate.”
“ Sodium deoxycholate and EDTA affected the rate of linoleic acid lipoxidase activity at pH 7.5 when calcium ions were present.”
Calcium ion activation of lipoxidase.
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