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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Deoxycholate
supplement:
Berberine Hydrochloride
Research Papers that Mention the Interaction
“After co-administration, the area under the plasma concentration–time curve of berberine chloride was increased 41.1-fold by C10 (100 mg/kg) and 35.3-fold by SDC (100 mg/kg) compared with that in the absence of C10 and SDC, respectively.”
“The results of the bioavailability experiments showed the oral absorption of berberine chloride was poor and both C10 and SDC could significantly improve the very poor absorption of berberine chloride.”
“This study demonstrates that C10 and SDC could significantly promote the absorption of berberine chloride from the gastrointestinal tract with few toxic effects, which might be due mainly to relaxing the absorption limitation while inhibiting the efflux transporter of berberine chloride by the enhancers.”
Enhancement by sodium caprate and sodium deoxycholate of the gastrointestinal absorption of berberine chloride in rats
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