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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dehydroepiandrosterone
drug:
Vancomycin
Research Papers that Mention the Interaction
“ DHEA affects the activity of positively‐charged antibiotics, including vancomycin.”
Attenuation of antimicrobial activity by the human steroid hormones“Background: Dehydroepiandrosterone DHEA ), a steroid present throughout life, can induce an increase in resistance to vancomycin in methicillin-sensitive and methicillin-resistant clinical isolates of Staphylococcus aureus.”
“However, DHEA significantly (p < 0.01) slowed the rate of vancomycin killing of sarA–. Conclusion: These data indicate that sarA may play a role in DHEA-mediated protection from vancomycin killing of S. aureus.”
Possible Role of sarA in Dehydroepiandrosterone-Mediated Increase in Staphylococcus aureus Resistance to Vancomycin
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