Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Dehydroepiandrosterone and Trilostane

Research Papers that Mention the Interaction

Trilostane suppressed the intracellular production of androstenedione, testosterone, and dihydrotestosterone from dehydroepiandrosterone in LNCaP-FGC cells.
Cancer letters  •  2010  |  View Paper
Trilostane is a competitive inhibitor of dehydroepiandrosterone with a Ki of 197 +/- 8 microM. The expression of the 3beta-hydroxysteroid dehydrogenase in Mtb is intracellular.
Biochemistry  •  2007  |  View Paper
Trilostane competitively inhibits the enzyme 3-beta hydroxysteroid dehydrogenase (3β-HSD), which converts pregnenolone (P5) to progesterone (P4) and dehydroepiandrosterone (DHEA) to androstendione (A4).
Veterinary Research Communications  •  2011  |  View Paper
Trilostane , aminogluthemide, or ICI 182,780 completely blocked the stimulatory effects of DHEA , suggesting that DHEA metabolites may stimulate aging somatotropes via estrogen receptors.
Endocrinology  •  2005  |  View Paper
In kinetic analyses of the conversion of DHA to 4-androstenedione, both trilostane and cyanoketone caused increases in the Km(app) for DHA which at the highest concentration used, were 15-fold the control Km(app) of 1.4 mumol/l.
The Journal of Steroid Biochemistry and Molecular Biology  •  1996  |  View Paper