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Last Updated: 2 years ago

Possible Interaction: Dehydroepiandrosterone and Tamoxifen

Research Papers that Mention the Interaction

Tamoxifen has been linked to the development of cholestasis, and it inhibits sulfotransferase 2A1 (SULT2A1)-catalyzed dehydroepiandrosterone ( DHEA ) sulfonation.
The Journal of Pharmacology and Experimental Therapeutics  •  2019  |  View Paper
The immunomodulatory effect of DHEA on PBMC cytokine release was completely blocked by tamoxifen.
Critical care medicine  •  2005  |  View Paper
A significant enhancement of growth and progesterone receptor expression was observed after treatment with E2 and DHEA , which was antagonized by the antiestrogen tamoxifen and not altered by the antiandrogen flutamide, supporting the involvement of estrogen receptors.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine  •  1993  |  View Paper
Moreover, tamoxifen counteracts in a dose-depended manner the stimulatory effect of DHEA and ADIOL, suggesting that it is mediated by an interaction with estrogen receptors.
Anticancer research  •  1992  |  View Paper
We conclude that tamoxifen stimulates adrenal production of DHEA , which is aromatized to E1 and E2.
Archives of surgery  •  1987  |  View Paper
For tamoxifen and alpha-hydroxytamoxifen the level of DNA adducts was reduced to approximately one-fifth by the addition of DHEAS (0.1 mM).
Carcinogenesis  •  1998  |  View Paper