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Last Updated: 5 months ago

Possible Interaction: Dehydroepiandrosterone Sulfate and Resveratrol

Research Papers that Mention the Interaction

In parallel, resveratrol induced a 22.2% decrease of dehydroepiandrosterone sulfate (P = .01), a decrease of fasting insulin level by 31.8% (P = .007) and an increase of the Insulin Sensitivity Index (Matsuda and DeFronzo) by 66.3% (P = .04).
The Journal of clinical endocrinology and metabolism  •  2016  |  View Paper
The results indicate that while resveratrol reduced the concentration of some androgen precursors, such as androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate , there were no effects on prostate size, prostate specific antigen, testosterone, free testosterone or dihydrotestosterone.
The Journal of urology  •  2016  |  View Paper
CONCLUSION In this population of middle-aged men suffering from MetS, high dose resveratrol (1,000 mg daily) administration for 4 months significantly lowered serum levels of the androgen precursors androstenedione, DHEA and DHEAS , whereas prostate size and circulating levels of PSA, testosterone, free testosterone, and dihydrotestosterone were unaffected.
The highest dose of resveratrol lowered the serum level of androstenedione 24% (P = 0.052), dehydroepiandrosterone (DHEA) 41% (P < 0.01), and dehydroepiandrosterone-sulphate (DHEAS) 50% (p<0.001), compared to the control group.
The Prostate  •  2015  |  View Paper
RES therefore … DHEA-S , E1-S, E2-S and E2-G formation in MCF-7, but not in MDA-MB-231 cells (Kis: E2-S, 0.73 ± … μM < E1-S, 0.94 ± 0.03 μM < E2-G, 7.92 ± 0.24 μM < DHEA-S, 13.2 ± 0.2 μM).
Front. Pharmacol.  •  2018  |  View Paper