Possible Interaction: Dehydroepiandrosterone Sulfate and Adrenocorticotropic Hormone

“In addition, the correlation was highly significant (P<0.001) between ACTH and DHEA-S at the term of HRT.”

“ ACTH administration caused a definite increase in plasma DS as compared to the control values, and there was no difference between young and aged groups in per cent increase in plasma DS values after ACTH stimulation.”

“ ACTH increased the mean AV concentration of DHEA-S by 5-fold, DHEA by 21-fold, A4 by 7-fold, and 11OHA by 5-fold.”

“A correlation was found between basal ACTH and DHEA-S values in the patients (r = 0.650; p = 0.05).”

“ ACTH stimulate secretion of cortisol and DHEA-S. Cortisol inhibits secretion of CRF and ACTH with negative feedback mechanism.”

“ ACTH treatment enhanced the secretion of cortisol and to a lesser extent that of DHAS , and increased the steroidogenic response to an acute stimulation with ACTH.”

“In this homosexual man, however, the plasma dehydroepiandrosterone sulfate (DHEA-S) values and the DHEA-S/1000 x A (A = androstenedione) ratio were increased before and after ACTH stimulation.”

“Continuous treatment with 1 nM ACTH increased dehydroepiandrosterone sulfate (DHAS) production 5- to 10-fold during the first 5 days in culture.”

“The addition of adrenocorticotropic hormone , forskolin, 22R-hydroxycholesterol, or dibutyryl cyclic adenosine monophosphate increased the secretion of dehydroepiandrosterone sulfate and cortisol twofold to threefold and twofold to sixfold, respectively, above basal rates.”

“When cells were incubated in the presence of adrenocorticotropic hormone , forskolin, 22R-hydroxycholesterol, or dibutyryl cyclic adenosine monophosphate plus atrial natriuretic polypeptide, cortisol secretion was inhibited 50% to 90% and dehydroepiandrosterone sulfate was inhibited 25% to 50%.”

“The production of both dehydroepiandrosterone sulfate and cortisol also was stimulated by ACTH , suggesting that the increased mRNAs were translated into active enzymes.”