Possible Interaction: Dehydroepiandrosterone and Steroids

“In conclusion, the present findings confirm that DHEA supplementation produces physiological and supraphysiological modifications in steroid milieu and adrenal function.”

“The administration of 200 mg of DHEA induced an increase of both steroids to supraphysiological plasma levels.”

“As the efficiencies of CYP7B1‐mediated hydroxylation of dehydroepiandrosterone and 3β‐Adiol are similar, we propose that varying steroid concentrations may be the most important factor determining the rate of CYP7B1‐mediated metabolism of dehydroepiandrosterone or 3β‐Adiol.”

“Dehydroepiandrosterone DHEA ) is synthesized in the brain and several studies have shown that this steroid is a modulator of synaptic transmission.”

“In light of the broad substrate specificity of this enzyme toward other steroids, in particular bile … cholesterol, the information presented forms a strong basis for further studies into the role of DHEA ST in modulating the activity of … number of biologically active and potentially toxic steroids in the … human.”

“Thus the high levels of 7-hydroxylase found in human mammary tumors, and acting on both DHEA and ADIOL, may function in controlling the intracellular concentrations of these steroids.”

“Correlation analysis between age and sex steroids revealed negative associations for the four sex steroids (T, DHEA , E2, and P).”

“ DHEA as substrate exerts a positive, feed‐forward up‐regulation on the 17β‐hydroxy steroid dehydrogenase‐5, which may imply that DHEA‐DHT tailor‐making in MSCs is subjected to chronobiological regulation.”

“The diagnostic value of salivary oestradiol, progesterone, testosterone, dehydroepiandrosterone and aldosterone testing is compromised by rapid fluctuations in salivary concentrations of these steroids.”

“ Steroid synthesis is blocked at the stage of the delta5 compounds pregnenolone, 17c~OH-pregnenolone and dehydroepiandrosterone (DHEA).”